gamma-Glutamylcyclotransferase

Medical Dictionary -> gamma-Glutamylcyclotransferase

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gamma-Glutamylcyclotransferase

An enzyme that catalyzes the synthesis of pyroglutamate from a gamma-glutamyl-amino acid, also releasing the free amino acid. The enzyme acts on derivatives of glutamate, 2-aminobutyrate, alanine and glycine. The enzyme has been proposed to have a role in a gamma-glutamyl cycle for amino acid transport into cells in the intestines. EC 2.3.2.4.