Receptors, Interleukin-2

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Receptors, Interleukin-2

Receptors present on activated T- and B-cells as a complex consisting of a 55-kDa peptide, which reacts with the anti-Tac monoclonal antibody, and a 75-kDa non-Tac interleukin-2-binding peptide. The receptor is present in two forms, one with a very high affinity and the other with low affinity for IL-2. The high-affinity form appears to mediate exclusively the growth-promoting response to IL-2. The receptor is present in large numbers on resting HUMAN T-LYMPHOTROPIC VIRUS 1 leukemia cells, but not on normal resting cells.