Proto-Oncogene Proteins c-met

Medical Dictionary -> Proto-Oncogene Proteins c-met

Proto-Oncogene Proteins c-met


Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consists of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations of the gene for PROTO-ONCOGENE PROTEINS C-MET are associated with papillary renal carcinoma and other neoplasia.


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