Metabolic Detoxication, Phase II

Medical Dictionary -> Metabolic Detoxication, Phase II

Metabolic Detoxication, Phase II


Conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.


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