Immunoglobulin Joining Region

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Immunoglobulin Joining Region

A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES, the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULINS, J CHAIN; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.