Coproporphyrinogen Oxidase

Medical Dictionary -> Coproporphyrinogen Oxidase

Coproporphyrinogen Oxidase


An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.


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