Bartter Syndrome
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Bartter Syndrome
A group of disorders caused by the defective salt reabsorption in the ascending LOOP OF HENLE. It is characterized by severe salt-wasting, HYPOKALEMIA, hypercalciuria, metabolic ALKALOSIS, and hyper-reninemic HYPERALDOSTERONISM without HYPERTENSION. There are several subtypes resulting from mutations of autosomal recessive genes for SODIUM-POTASSIUM-CHLORIDE COTRANSPORTERS.
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