Activating Transcription Factor 6

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Activating Transcription Factor 6


A BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.

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